NCL1, a highly selective lysine-specific demethylase 1 inhibitor, suppresses prostate cancer without adverse effect

Herein, we investigated therapeutic potential of a novel histone lysine demethylase 1 (LSD1) inhibitor, NCL1, in prostate cancer. Hormone-sensitive prostate cancer cells, (LNCaP) and castration resistant cancer cells (PC3 and PCai1) were treated with NCL1, and LSD1 expression and cell viability were...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Etani, Toshiki, Suzuki, Takayoshi, Naiki, Taku, Naiki-Ito, Aya, Ando, Ryosuke, Iida, Keitaro, Kawai, Noriyasu, Tozawa, Keiichi, Miyata, Naoki, Kohri, Kenjiro, Takahashi, Satoru
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2014
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413623/
https://ncbi.nlm.nih.gov/pubmed/25605246
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