The Evolutionary History of Lethal Metastatic Prostate Cancer

Cancers emerge from an on-going Darwinian evolutionary process, often leading to multiple competing subclones within a single primary tumour(1-4). This evolutionary process culminates in the formation of metastases, which is the cause of 90% of cancer-related deaths(5). However, despite its clinical...

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Publicado no:Nature
Main Authors: Gundem, Gunes, Van Loo, Peter, Kremeyer, Barbara, Alexandrov, Ludmil B., Tubio, Jose M.C., Papaemmanuil, Elli, Brewer, Daniel S., Kallio, Heini M.L., Högnäs, Gunilla, Annala, Matti, Kivinummi, Kati, Goody, Victoria, Latimer, Calli, O’Meara, Sarah, Dawson, Kevin J., Isaacs, William, Emmert-Buck, Michael R, Nykter, Matti, Foster, Christopher, Kote-Jarai, Zsofia, Easton, Douglas, Whitaker, Hayley C., Neal, David E., Cooper, Colin S., Eeles, Rosalind A., Visakorpi, Tapio, Campbell, Peter J., McDermott, Ultan, Wedge, David C., Bova, G. Steven
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413032/
https://ncbi.nlm.nih.gov/pubmed/25830880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14347
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