Fatty acid carbon is essential for dNTP synthesis in endothelial cells

The metabolism of endothelial cells (ECs) during vessel sprouting remains poorly studied. Here, we report that endothelial loss of CPT1a, a rate-limiting enzyme of fatty acid oxidation (FAO), caused vascular sprouting defects due to impaired proliferation, not migration of ECs. Reduction of FAO in E...

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Publicado en:Nature
Main Authors: Schoors, Sandra, Bruning, Ulrike, Missiaen, Rindert, Queiroz, Karla CS, Borgers, Gitte, Elia, Ilaria, Zecchin, Annalisa, Cantelmo, Anna Rita, Christen, Stefan, Goveia, Jermaine, Heggermont, Ward, Goddé, Lucica, Vinckier, Stefan, Van Veldhoven, Paul P., Eelen, Guy, Schoonjans, Luc, Gerhardt, Holger, Dewerchin, Mieke, Baes, Myriam, De Bock, Katrien, Ghesquière, Bart, Lunt, Sophia Y., Fendt, Sarah-Maria, Carmeliet, Peter
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413024/
https://ncbi.nlm.nih.gov/pubmed/25830893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14362
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