The mTOR Inhibitor Rapamycin Suppresses DNA Double-Strand Break Repair

mTOR (mammalian target of rapamycin) signaling plays a key role in the development of many tumor types. Therefore, mTOR is an attractive target for cancer therapeutics. Although mTOR inhibitors are thought to have radiosensitization activity, the molecular bases remain largely unknown. Here we show...

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Pubblicato in:Radiat Res
Autori principali: Chen, Honghong, Ma, Zhefu, Vanderwaal, Robert P., Feng, Zhihui, Gonzalez-Suarez, Ignacio, Wang, Shenming, Zhang, Jiuqin, Roti Roti, Joseph L., Gonzalo, Susana, Zhang, Junran
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4412148/
https://ncbi.nlm.nih.gov/pubmed/21268715
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