Targeting the late component of the cardiac L-type Ca(2+) current to suppress early afterdepolarizations

Early afterdepolarizations (EADs) associated with prolongation of the cardiac action potential (AP) can create heterogeneity of repolarization and premature extrasystoles, triggering focal and reentrant arrhythmias. Because the L-type Ca(2+) current (I(Ca,L)) plays a key role in both AP prolongation...

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Udgivet i:J Gen Physiol
Main Authors: Madhvani, Roshni V., Angelini, Marina, Xie, Yuanfang, Pantazis, Antonios, Suriany, Silvie, Borgstrom, Nils P., Garfinkel, Alan, Qu, Zhilin, Weiss, James N., Olcese, Riccardo
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2015
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4411259/
https://ncbi.nlm.nih.gov/pubmed/25918358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201411288
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