SIRT3 Overexpression Attenuates Palmitate-Induced Pancreatic β-Cell Dysfunction

Abnormally high levels of circulating free fatty acids can lead to pancreatic islet β-cell dysfunction and apoptosis, contributing to β-cell failure in Type 2 diabetes. The NAD(+)-dependent protein deacetylase Sirtuin-3 (SIRT3) has been implicated in Type 2 diabetes. In this study, we tested whether...

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Publicado en:PLoS One
Autores principales: Kim, Min, Lee, Ji Seon, Oh, Joo En, Nan, Jinyan, Lee, Hakmo, Jung, Hye Seung, Chung, Sung Soo, Park, Kyong Soo
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4411148/
https://ncbi.nlm.nih.gov/pubmed/25915406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124744
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