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SIRT6 protects against palmitate-induced pancreatic β-cell dysfunction and apoptosis
Chronic exposure of pancreatic β-cells to abnormally elevated levels of free fatty acids can lead to β-cell dysfunction and even apoptosis, contributing to type 2 diabetes pathogenesis. In pancreatic β-cells, SIRT6 has been shown to regulate insulin secretion in response to glucose stimulation. Howe...
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| 出版年: | J Endocrinol |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5365398/ https://ncbi.nlm.nih.gov/pubmed/27601447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-16-0317 |
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