DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier

Self-renewal is the hallmark feature both of normal stem cells and cancer stem cells(1). Since the regenerative capacity of normal haematopoietic stem cells is limited by the accumulation of reactive oxygen species and DNA double-strand breaks(2–4), we speculated that DNA damage might also constrain...

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Publicado no:Nature
Main Authors: Santos, Margarida A., Faryabi, Robert B., Ergen, Aysegul V., Day, Amanda M., Malhowski, Amy, Canela, Andres, Onozawa, Masahiro, Lee, Ji-Eun, Callen, Elsa, Gutierrez-Martinez, Paula, Chen, Hua-Tang, Wong, Nancy, Finkel, Nadia, Deshpande, Aniruddha, Sharrow, Susan, Rossi, Derrick J., Ito, Keisuke, Ge, Kai, Aplan, Peter D., Armstrong, Scott A., Nussenzweig, André
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4410707/
https://ncbi.nlm.nih.gov/pubmed/25079327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13483
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