DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier

Self-renewal is the hallmark feature both of normal stem cells and cancer stem cells(1). Since the regenerative capacity of normal haematopoietic stem cells is limited by the accumulation of reactive oxygen species and DNA double-strand breaks(2–4), we speculated that DNA damage might also constrain...

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Pubblicato in:Nature
Autori principali: Santos, Margarida A., Faryabi, Robert B., Ergen, Aysegul V., Day, Amanda M., Malhowski, Amy, Canela, Andres, Onozawa, Masahiro, Lee, Ji-Eun, Callen, Elsa, Gutierrez-Martinez, Paula, Chen, Hua-Tang, Wong, Nancy, Finkel, Nadia, Deshpande, Aniruddha, Sharrow, Susan, Rossi, Derrick J., Ito, Keisuke, Ge, Kai, Aplan, Peter D., Armstrong, Scott A., Nussenzweig, André
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4410707/
https://ncbi.nlm.nih.gov/pubmed/25079327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13483
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