Kaiso mainly locates in the nucleus in vivo and binds to methylated, but not hydroxymethylated DNA

OBJECTIVE: Kaiso is upregulated in many cancers and proposed to bind with both methylated- and unmethylated-DNA in the nucleus as a transcriptional repressor. The objective is to define its subcellular localization in vivo and exact binding DNA sequences in cells. METHODS: Compartmentalization of ex...

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Bibliographic Details
Published in:Chin J Cancer Res
Main Authors: Qin, Sisi, Zhang, Baozhen, Tian, Wei, Gu, Liankun, Lu, Zheming, Deng, Dajun
Format: Artigo
Language:Inglês
Published: AME Publishing Company 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409972/
https://ncbi.nlm.nih.gov/pubmed/25937776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3978/j.issn.1000-9604.2015.04.03
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