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Targeting of metastasis-promoting tumor-associated fibroblasts and modulation of pancreatic tumor-associated stroma with a carboxymethylcellulose-docetaxel nanoparticle

Pancreatic ductal adenocarcinomas are characterized by the desmoplastic reaction, a dense fibrous stroma that has been shown to be supportive of tumor cell growth, invasion, and metastasis, and has been associated with resistance to chemotherapy and reduced patient survival. Here, we investigated ta...

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Publicat a:J Control Release
Autors principals: Ernsting, Mark J., Hoang, Bryan, Lohse, Ines, Undzys, Elijus, Cao, Pinjiang, Do, Trevor, Gill, Bethany, Pintilie, Melania, Hedley, David, Li, Shyh-Dar
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409566/
https://ncbi.nlm.nih.gov/pubmed/25804872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2015.03.023
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