Chronic Deletion and Acute Knockdown of Parkin Have Differential Responses to Acetaminophen-induced Mitophagy and Liver Injury in Mice

We previously demonstrated that pharmacological induction of autophagy protected against acetaminophen (APAP)-induced liver injury in mice by clearing damaged mitochondria. However, the mechanism for removal of mitochondria by autophagy is unknown. Parkin, an E3 ubiquitin ligase, has been shown to b...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Williams, Jessica A., Ni, Hong-Min, Haynes, Anna, Manley, Sharon, Li, Yuan, Jaeschke, Hartmut, Ding, Wen-Xing
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2015
Pynciau:
Molecular Bases of Disease
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409255/
https://ncbi.nlm.nih.gov/pubmed/25752611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.602284
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