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Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver()

Acetaminophen (APAP) overdose is the most frequent cause of acute liver failure in the US and many western countries. It is well known that APAP induces mitochondrial damage to trigger centrilobular necrosis. Emerging evidence suggests that autophagic removal of damaged mitochondria may protect agai...

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Bibliografski detalji
Glavni autori: Ni, Hong-Min, Williams, Jessica A, Jaeschke, Hartmut, Ding, Wen-Xing
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814950/
https://ncbi.nlm.nih.gov/pubmed/24191236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2013.08.005
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