Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix, while promoting vascular rarefaction through angiopoietin-2 upregulation

RATIONALE: Diabetes is associated with cardiac fibrosis. Matricellular proteins are induced in fibrotic conditions and modulate fibrogenic and angiogenic responses by regulating growth factor signaling. OBJECTIVE: To test the hypothesis that the prototypical matricellular protein thrombospondin (TSP...

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Foilsithe in:Circ Res
Main Authors: Gonzalez-Quesada, Carlos, Cavalera, Michele, Biernacka, Anna, Kong, Ping, Lee, Dong-Wook, Saxena, Amit, Frunza, Olga, Dobaczewski, Marcin, Shinde, Arti, Frangogiannis, Nikolaos G
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408537/
https://ncbi.nlm.nih.gov/pubmed/24081879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.113.302593
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