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ENDOGENOUS THROMBOSPONDIN-1 PROTECTS THE PRESSURE-OVERLOADED MYOCARDIUM BY MODULATING FIBROBLAST PHENOTYPE AND MATRIX METABOLISM
The matricellular protein Thrombospondin (TSP)-1 is induced following tissue injury and may regulate reparative responses by activating TGF-β, by suppressing angiogenesis, and by modulating inflammation and matrix metabolism. We hypothesized that endogenous TSP-1 may be involved in the pathogenesis...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3199343/ https://ncbi.nlm.nih.gov/pubmed/21947471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.111.175323 |
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