ENDOGENOUS THROMBOSPONDIN-1 PROTECTS THE PRESSURE-OVERLOADED MYOCARDIUM BY MODULATING FIBROBLAST PHENOTYPE AND MATRIX METABOLISM

The matricellular protein Thrombospondin (TSP)-1 is induced following tissue injury and may regulate reparative responses by activating TGF-β, by suppressing angiogenesis, and by modulating inflammation and matrix metabolism. We hypothesized that endogenous TSP-1 may be involved in the pathogenesis...

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Main Authors: Xia, Ying, Dobaczewski, Marcin, Gonzalez-Quesada, Carlos, Chen, Wei, Biernacka, Anna, Li, Na, Lee, Dong-Wook, Frangogiannis, Nikolaos G
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199343/
https://ncbi.nlm.nih.gov/pubmed/21947471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.111.175323
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