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Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix, while promoting vascular rarefaction through angiopoietin-2 upregulation
RATIONALE: Diabetes is associated with cardiac fibrosis. Matricellular proteins are induced in fibrotic conditions and modulate fibrogenic and angiogenic responses by regulating growth factor signaling. OBJECTIVE: To test the hypothesis that the prototypical matricellular protein thrombospondin (TSP...
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| Publicado no: | Circ Res |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4408537/ https://ncbi.nlm.nih.gov/pubmed/24081879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.113.302593 |
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