CXCR3-independent actions of the CXC chemokine CXCL10 in the infarcted myocardium and in isolated cardiac fibroblasts are mediated through proteoglycans

AIMS: The CXC chemokine CXCL10 is up-regulated in the infarcted myocardium and limits cardiac fibrosis by inhibiting growth factor-mediated fibroblast migration. CXCL10 signals by binding to its receptor CXCR3; however, recently CXCR3-independent CXCL10 actions have been suggested. Our study explore...

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Detalhes bibliográficos
Main Authors: Saxena, Amit, Bujak, Marcin, Frunza, Olga, Dobaczewski, Marcin, Gonzalez-Quesada, Carlos, Lu, Bao, Gerard, Craig, Frangogiannis, Nikolaos G.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148609/
https://ncbi.nlm.nih.gov/pubmed/24891401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvu138
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