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Modified T4 lysozyme fusion proteins facilitate G Protein-coupled receptor crystallogenesis
G protein-coupled receptors (GPCRs) mediate the majority of cellular responses to hormones and neurotransmitters. The majority of GPCR crystal structures have been obtained using a fusion protein strategy, where the flexible third intracellular loop is replaced by T4 lysozyme (T4L). However, wild-ty...
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| Publicado no: | Structure |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4408211/ https://ncbi.nlm.nih.gov/pubmed/25450769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.08.022 |
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