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The Molecular Basis of G Protein–Coupled Receptor Activation
G protein–coupled receptors (GPCRs) mediate the majority of cellular responses to external stimuli. Upon activation by a ligand, the receptor binds to a partner heterotrimeric G protein and promotes exchange of GTP for GDP, leading to dissociation of the G protein into α and βγ subunits that mediate...
Gardado en:
| Publicado en: | Annu Rev Biochem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6535337/ https://ncbi.nlm.nih.gov/pubmed/29925258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-biochem-060614-033910 |
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