Direct Detection of α-Synuclein Dimerization Dynamics: Single-Molecule Fluorescence Analysis

The aggregation of α-synuclein (α-Syn) is linked to Parkinson’s disease. The mechanism of early aggregation steps and the effect of pathogenic single-point mutations remain elusive. We report here a single-molecule fluorescence study of α-Syn dimerization and the effect of mutations. Specific intera...

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Publicat a:Biophys J
Autors principals: Lv, Zhengjian, Krasnoslobodtsev, Alexey V., Zhang, Yuliang, Ysselstein, Daniel, Rochet, Jean-Christophe, Blanchard, Scott C., Lyubchenko, Yuri L.
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2015
Matèries:
Proteins and Nucleic Acids
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407253/
https://ncbi.nlm.nih.gov/pubmed/25902443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.03.010
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