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Alpha-synuclein misfolding assessed with single molecule AFM force spectroscopy: Effect of pathogenic mutations
Misfolding and subsequent aggregation of alpha-synuclein (α-Syn) protein are critically involved in the development of several neurodegenerative diseases, including Parkinson’s disease (PD). Three familial single point mutations, A30P, E46K, and A53T, correlate with early-onset PD; however the molec...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3844294/ https://ncbi.nlm.nih.gov/pubmed/24066883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401037z |
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