Alpha-synuclein misfolding assessed with single molecule AFM force spectroscopy: Effect of pathogenic mutations

Misfolding and subsequent aggregation of alpha-synuclein (α-Syn) protein are critically involved in the development of several neurodegenerative diseases, including Parkinson’s disease (PD). Three familial single point mutations, A30P, E46K, and A53T, correlate with early-onset PD; however the molec...

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Bibliografiske detaljer
Main Authors: Krasnoslobodtsev, Alexey V., Volkov, Ivan L., Asiago, Josephat M., Hindupur, Jagadish, Rochet, Jean-Christophe, Lyubchenko, Yuri L.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3844294/
https://ncbi.nlm.nih.gov/pubmed/24066883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401037z
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