Combination of Alphavirus replicon particle-based vaccination with immunomodulatory antibodies: therapeutic activity in the B16 melanoma mouse model and immune correlates

Induction of potent immune responses to self-antigens remains a major challenge in tumor immunology. We have shown that a vaccine based on alphavirus replicon particles (VRP) activates strong cellular and humoral immunity to tyrosinase related protein-2 (TRP2) melanoma antigen, providing prophylacti...

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Publicado en:Cancer Immunol Res
Main Authors: Avogadri, Francesca, Zappasodi, Roberta, Yang, Arvin, Budhu, Sadna, Malandro, Nicole, Hirshhorn-Cymerman, Daniel, Tiwari, Shakuntala, Maughan, Maureen F., Olmsted, Robert, Wolchok, Jedd D, Merghoub, Taha
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406637/
https://ncbi.nlm.nih.gov/pubmed/24795357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-13-0220
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