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XIAP and cIAP1 amplifications induce Beclin 1-dependent autophagy through NFκB activation

Perturbations in autophagy and apoptosis are associated with cancer development. XIAP and cIAP1 are two members of the inhibitors of apoptosis protein family whose expression is elevated in different cancers. Here we report that XIAP and cIAP1 induce autophagy by upregulating the transcription of Be...

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Vydáno v:Hum Mol Genet
Hlavní autoři: Lin, Fang, Ghislat, Ghita, Luo, Shouqing, Renna, Maurizio, Siddiqi, Farah, Rubinsztein, David C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406300/
https://ncbi.nlm.nih.gov/pubmed/25669656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv052
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