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Mitochondrial complex I deficiency leads to inflammation and retinal ganglion cell death in the Ndufs4 mouse
Mitochondrial complex I (NADH dehydrogenase) is a major contributor to neuronal energetics, and mutations in complex I lead to vision loss. Functional, neuroanatomical and transcriptional consequences of complex I deficiency were investigated in retinas of the Ndufs4 knockout mouse. Whole-eye ERGs a...
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| Publicado no: | Hum Mol Genet |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4406296/ https://ncbi.nlm.nih.gov/pubmed/25652399 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv045 |
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