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Mitochondrial complex I deficiency leads to the retardation of early embryonic development in Ndufs4 knockout mice
BACKGROUND: The NDUFS4 gene encodes an 18-kD subunit of mitochondria complex I, and mutations in this gene lead to the development of a severe neurodegenerative disease called Leigh syndrome (LS) in humans. To investigate the disease phenotypes and molecular mechanisms of Leigh syndrome, the Ndufs4...
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| Veröffentlicht in: | PeerJ |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
PeerJ Inc.
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5438584/ https://ncbi.nlm.nih.gov/pubmed/28533980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.3339 |
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