Increased CRF signaling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal

Increased anxiety is a predominant withdrawal symptom in abstinent smokers, yet the neuroanatomical and molecular bases underlying it are unclear. Here, we show that withdrawal-induced anxiety increases activity of neurons in the interpeduncular intermediate (IPI), a subregion of the interpeduncular...

Full description

Saved in:
Bibliographic Details
Published in:Nat Commun
Main Authors: Zhao-Shea, Rubing, DeGroot, Steven R., Liu, Liwang, Vallaster, Markus, Pang, Xueyan, Su, Qin, Gao, Guangping, Rando, Oliver J., Martin, Gilles E., George, Olivier, Gardner, Paul D., Tapper, Andrew R.
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405813/
https://ncbi.nlm.nih.gov/pubmed/25898242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7770
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items