Increased CRF signaling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal

Increased anxiety is a predominant withdrawal symptom in abstinent smokers, yet the neuroanatomical and molecular bases underlying it are unclear. Here, we show that withdrawal-induced anxiety increases activity of neurons in the interpeduncular intermediate (IPI), a subregion of the interpeduncular...

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Pubblicato in:Nat Commun
Autori principali: Zhao-Shea, Rubing, DeGroot, Steven R., Liu, Liwang, Vallaster, Markus, Pang, Xueyan, Su, Qin, Gao, Guangping, Rando, Oliver J., Martin, Gilles E., George, Olivier, Gardner, Paul D., Tapper, Andrew R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405813/
https://ncbi.nlm.nih.gov/pubmed/25898242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7770
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