Nicotine Persistently Activates Ventral Tegmental Area Dopaminergic Neurons via Nicotinic Acetylcholine Receptors Containing α4 and α6 Subunits

Nicotine is reinforcing because it activates dopaminergic (DAergic) neurons within the ventral tegmental area (VTA) of the brain's mesocorticolimbic reward circuitry. This increase in activity can occur for a period of several minutes up to an hour and is thought to be a critical component of n...

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Autori principali: Liu, Liwang, Zhao-Shea, Rubing, McIntosh, J. Michael, Gardner, Paul D., Tapper, Andrew R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310415/
https://ncbi.nlm.nih.gov/pubmed/22222765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.076661
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