Lentivirus-mediated expression of cDNA and shRNA slows degeneration in retinitis pigmentosa

Mutations in Pde6b lead to high levels of signaling molecules cyclic guanosine monophosphate (cGMP) and Ca(2+), which ultimately result in photoreceptor cell death in certain forms of retinitis pigmentosa (RP). The level of cGMP, which is controlled by opposing activities of guanylate cyclase (GUCY)...

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Pubblicato in:Exp Biol Med (Maywood)
Autori principali: Tosi, Joaquin, Sancho-Pelluz, Javier, Davis, Richard J, Hsu, Chun Wei, Wolpert, Kyle V, Sengillo, Jesse D, Lin, Chyuan-Sheng, Tsang, Stephen H
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405537/
https://ncbi.nlm.nih.gov/pubmed/21885480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1258/ebm.2011.011053
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