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Lentivirus-mediated expression of cDNA and shRNA slows degeneration in retinitis pigmentosa
Mutations in Pde6b lead to high levels of signaling molecules cyclic guanosine monophosphate (cGMP) and Ca(2+), which ultimately result in photoreceptor cell death in certain forms of retinitis pigmentosa (RP). The level of cGMP, which is controlled by opposing activities of guanylate cyclase (GUCY)...
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| Vydáno v: | Exp Biol Med (Maywood) |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4405537/ https://ncbi.nlm.nih.gov/pubmed/21885480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1258/ebm.2011.011053 |
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