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Therapeutic Margins in a Novel Preclinical Model of Retinitis Pigmentosa
The third-most common cause of autosomal recessive retinitis pigmentosa (RP) is due to defective cGMP phosphodiesterase-6 (PDE6). Previous work using viral gene therapy on PDE6-mutant mouse models demonstrated photoreceptors can be rescued if administered before degeneration. However, whether visual...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Society for Neuroscience
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3742933/ https://ncbi.nlm.nih.gov/pubmed/23946405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0419-13.2013 |
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