Therapeutic Margins in a Novel Preclinical Model of Retinitis Pigmentosa

The third-most common cause of autosomal recessive retinitis pigmentosa (RP) is due to defective cGMP phosphodiesterase-6 (PDE6). Previous work using viral gene therapy on PDE6-mutant mouse models demonstrated photoreceptors can be rescued if administered before degeneration. However, whether visual...

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Main Authors: Davis, Richard J., Hsu, Chun-Wei, Tsai, Yi-Ting, Wert, Katherine J., Sancho-Pelluz, Javier, Lin, Chyuan-Sheng, Tsang, Stephen H.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742933/
https://ncbi.nlm.nih.gov/pubmed/23946405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0419-13.2013
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