Silencing of Tuberin Enhances Photoreceptor Survival and Function in a Preclinical Model of Retinitis Pigmentosa (An American Ophthalmological Society Thesis)

PURPOSE: To assess the functional consequences of silencing of tuberin, an inhibitor of the mTOR signaling pathway, in a preclinical model of retinitis pigmentosa (RP) in order to test the hypothesis that insufficient induction of the protein kinase B (PKB)-regulated tuberin/mTOR self-survival pathw...

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Detalhes bibliográficos
Publicado no:Trans Am Ophthalmol Soc
Main Authors: Tsang, Stephen H., Chan, Lawrence, Tsai, Yi-Ting, Wu, Wen-Hsuan, Hsu, Chun-Wei, Yang, Jin, Tosi, Joaquin, Wert, Katherine J., Davis, Richard J., Mahajan, Vinit B.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Ophthalmological Society 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311672/
https://ncbi.nlm.nih.gov/pubmed/25646031
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