CRISPR Repair Reveals Causative Mutation in a Preclinical Model of Retinitis Pigmentosa

Massive parallel sequencing enables identification of numerous genetic variants in mutant organisms, but determining pathogenicity of any one mutation can be daunting. The most commonly studied preclinical model of retinitis pigmentosa called the “rodless” (rd1) mouse is homozygous for two mutations...

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Detalles Bibliográficos
Publicado en:Mol Ther
Main Authors: Wu, Wen-Hsuan, Tsai, Yi-Ting, Justus, Sally, Lee, Ting-Ting, Zhang, Lijuan, Lin, Chyuan-Sheng, Bassuk, Alexander G, Mahajan, Vinit B, Tsang, Stephen H
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023380/
https://ncbi.nlm.nih.gov/pubmed/27203441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.107
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