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Gene therapy provides long-term visual function in a pre-clinical model of retinitis pigmentosa
Approximately 36 000 cases of simplex and familial retinitis pigmentosa (RP) worldwide are caused by a loss in phosphodiesterase (PDE6) function. In the preclinical Pde6α(nmf363) mouse model of this disease, defects in the α-subunit of PDE6 result in a progressive loss of photoreceptors and neuronal...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3542865/ https://ncbi.nlm.nih.gov/pubmed/23108158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds466 |
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