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The molecular basis of antifolate resistance in Plasmodium falciparum: looking beyond point mutations
Drugs that target the folate synthesis pathway have a long history of effectiveness against a variety of pathogens. As antimalarials, the antifolates were safe and well tolerated, but resistance emerged quickly and has persisted even with decreased drug pressure. The primary determinants of resistan...
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| 發表在: | Ann N Y Acad Sci |
|---|---|
| Main Authors: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4405445/ https://ncbi.nlm.nih.gov/pubmed/25694157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.12662 |
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