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The molecular basis of antifolate resistance in Plasmodium falciparum: looking beyond point mutations

Drugs that target the folate synthesis pathway have a long history of effectiveness against a variety of pathogens. As antimalarials, the antifolates were safe and well tolerated, but resistance emerged quickly and has persisted even with decreased drug pressure. The primary determinants of resistan...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Ann N Y Acad Sci
मुख्य लेखकों: Heinberg, Adina, Kirkman, Laura
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2015
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405445/
https://ncbi.nlm.nih.gov/pubmed/25694157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.12662
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