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Knockdown of T-bet expression in Mart-1(27–35)-specific T-cell-receptor-engineered human CD4(+) CD25(−) and CD8(+) T cells attenuates effector function

Gene transfer to create tumour epitope-specific cytolytic T cells for adoptive immunotherapy of cancer remains an area of active inquiry. When the Mart-1(27–35)-specific DMF5 T-cell receptor (TCR) is transferred into peripheral human CD4(+) T cells, the reprogrammed cells exhibit a T helper type 1 (...

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Detalhes bibliográficos
Publicado no:Immunology
Main Authors: Jha, Sidharth S, Chakraborty, Nitya G, Singh, Prashant, Mukherji, Bijay, Dorsky, David I
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405330/
https://ncbi.nlm.nih.gov/pubmed/25495780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12431
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