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Knockdown of T-bet expression in Mart-1(27–35)-specific T-cell-receptor-engineered human CD4(+) CD25(−) and CD8(+) T cells attenuates effector function
Gene transfer to create tumour epitope-specific cytolytic T cells for adoptive immunotherapy of cancer remains an area of active inquiry. When the Mart-1(27–35)-specific DMF5 T-cell receptor (TCR) is transferred into peripheral human CD4(+) T cells, the reprogrammed cells exhibit a T helper type 1 (...
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| Publicat a: | Immunology |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BlackWell Publishing Ltd
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4405330/ https://ncbi.nlm.nih.gov/pubmed/25495780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12431 |
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