Enhancement of CD8(+) T-cell memory by removal of a vaccinia virus nuclear factor-κB inhibitor

Factors influencing T-cell responses are important for vaccine development but are incompletely understood. Here, vaccinia virus (VACV) protein N1 is shown to impair the development of both effector and memory CD8(+) T cells and this correlates with its inhibition of nuclear factor-κB (NF-κB) activa...

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Bibliographic Details
Published in:Immunology
Main Authors: Ren, Hongwei, Ferguson, Brian J, de Motes, Carlos Maluquer, Sumner, Rebecca P, Harman, Laura E R, Smith, Geoffrey L
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2015
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405322/
https://ncbi.nlm.nih.gov/pubmed/25382035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12422
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