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Increased attenuation but decreased immunogenicity by deletion of multiple vaccinia virus immunomodulators
Vaccinia virus (VACV)-derived vectors are popular candidates for vaccination against diseases such as HIV-1, malaria and tuberculosis. However, their genomes encode a multitude of proteins with immunomodulatory functions, several of which reduce the immunogenicity of these vectors. Hitherto only lim...
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| Veröffentlicht in: | Vaccine |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier Science
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5022402/ https://ncbi.nlm.nih.gov/pubmed/27544585 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2016.08.002 |
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