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Single-cell genotyping demonstrates complex clonal diversity in acute myeloid leukemia

Clonal evolution in cancer – the selection for and emergence of increasingly malignant clones during progression and therapy, resulting in cancer metastasis and relapse – has been highlighted as an important phenomenon in the biology of leukemia and other cancers. Tracking mutant alleles to determin...

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Detalles Bibliográficos
Publicado en:Sci Transl Med
Main Authors: Paguirigan, Amy L., Smith, Jordan, Meshinchi, Soheil, Carroll, Martin, Maley, Carlo, Radich, Jerald P.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405099/
https://ncbi.nlm.nih.gov/pubmed/25834112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaa0763
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