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Reducing toxicity of 4–1BB costimulation: targeting 4–1BB ligands to the tumor stroma with bi-specific aptamer conjugates

Systemic administration of immune modulatory antibodies to cancer patients is associated with autoimmune pathologies. We have developed a clinically feasible and broadly applicable approach to limit immune stimulation to disseminated tumor lesions using a bi-specific agonistic 4–1BB oligonucleotide...

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Bibliografiske detaljer
Udgivet i:Oncoimmunology
Main Authors: Schrand, B, Berezhnoy, A, Brenneman, R, Williams, A, Levay, A, Gilboa, E
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404909/
https://ncbi.nlm.nih.gov/pubmed/25949891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/21624011.2014.970918
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