Mefenamic acid taste-masked oral disintegrating tablets with enhanced solubility via molecular interaction produced by hot melt extrusion technology

The objective of this study was to enhance the solubility as well as to mask the intensely bitter taste of the poorly soluble drug, Mefenamic acid (MA). The taste masking and solubility of the drug was improved by using Eudragit(®) E PO in different ratios via hot melt extrusion (HME), solid dispers...

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Detalhes bibliográficos
Publicado no:J Drug Deliv Sci Technol
Main Authors: Alshehri, Sultan M., Park, Jun-Bom, Alsulays, Bader B., Tiwari, Roshan V., Almutairy, Bjad, Alshetaili, Abdullah S., Morott, Joseph, Shah, Sejal, Kulkarni, Vijay, Majumdar, Soumyajit, Martin, Scott T., Mishra, Sanjay, Wang, Lijia, Repka, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404746/
https://ncbi.nlm.nih.gov/pubmed/25914727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jddst.2015.03.003
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