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Base Excision Repair Enzymes Protect Abasic Sites in Duplex DNA from Interstrand Cross-Links
Hydrolysis of the N-glycosyl bond between a nucleobase and deoxyribose leaves an abasic site within duplex DNA. The abasic site can react with exocyclic amines of nucleobases on the complementary strand to form interstrand DNA-DNA cross-links (ICLs). We find that several enzymes from the base excisi...
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| Publicado en: | Biochemistry |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4404639/ https://ncbi.nlm.nih.gov/pubmed/25679877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501491z |
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