Deep Sequencing of Protease Inhibitor Resistant HIV Patient Isolates Reveals Patterns of Correlated Mutations in Gag and Protease

While the role of drug resistance mutations in HIV protease has been studied comprehensively, mutations in its substrate, Gag, have not been extensively cataloged. Using deep sequencing, we analyzed a unique collection of longitudinal viral samples from 93 patients who have been treated with therapi...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Flynn, William F., Chang, Max W., Tan, Zhiqiang, Oliveira, Glenn, Yuan, Jinyun, Okulicz, Jason F., Torbett, Bruce E., Levy, Ronald M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404092/
https://ncbi.nlm.nih.gov/pubmed/25894830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004249
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