Deep Sequencing of Protease Inhibitor Resistant HIV Patient Isolates Reveals Patterns of Correlated Mutations in Gag and Protease

While the role of drug resistance mutations in HIV protease has been studied comprehensively, mutations in its substrate, Gag, have not been extensively cataloged. Using deep sequencing, we analyzed a unique collection of longitudinal viral samples from 93 patients who have been treated with therapi...

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Gepubliceerd in:PLoS Comput Biol
Hoofdauteurs: Flynn, William F., Chang, Max W., Tan, Zhiqiang, Oliveira, Glenn, Yuan, Jinyun, Okulicz, Jason F., Torbett, Bruce E., Levy, Ronald M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404092/
https://ncbi.nlm.nih.gov/pubmed/25894830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004249
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