Deep Sequencing of Protease Inhibitor Resistant HIV Patient Isolates Reveals Patterns of Correlated Mutations in Gag and Protease

While the role of drug resistance mutations in HIV protease has been studied comprehensively, mutations in its substrate, Gag, have not been extensively cataloged. Using deep sequencing, we analyzed a unique collection of longitudinal viral samples from 93 patients who have been treated with therapi...

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Bibliografiske detaljer
Udgivet i:PLoS Comput Biol
Main Authors: Flynn, William F., Chang, Max W., Tan, Zhiqiang, Oliveira, Glenn, Yuan, Jinyun, Okulicz, Jason F., Torbett, Bruce E., Levy, Ronald M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404092/
https://ncbi.nlm.nih.gov/pubmed/25894830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004249
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