Soluble T Cell Immunoglobulin Mucin Domain 3 Is Shed from CD8(+) T Cells by the Sheddase ADAM10, Is Increased in Plasma during Untreated HIV Infection, and Correlates with HIV Disease Progression

Chronic HIV infection results in a loss of HIV-specific CD8(+) T cell effector function, termed “exhaustion,” which is mediated, in part, by the membrane coinhibitory receptor T cell immunoglobulin mucin domain-3 (Tim-3). Like many other receptors, a soluble form of this protein has been described i...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Clayton, Kiera L., Douglas-Vail, Matthew B., Rahman, A. K. M. Nur-ur, Medcalf, Karyn E., Xie, Irene Y., Chew, Glen M., Tandon, Ravi, Lanteri, Marion C., Norris, Philip J., Deeks, Steven G., Ndhlovu, Lishomwa C., Ostrowski, Mario A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403393/
https://ncbi.nlm.nih.gov/pubmed/25609823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00006-15
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