T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) is recruited to the immune synapse, disrupts stable synapse formation and associates with receptor phosphatases

CD8(+) cytotoxic T lymphocytes (CTL) are adept at killing virally infected cells and cancer cells and releasing cytokines (e.g. IFN-γ) to aid this response. However, during cancer and chronic viral infections, such as with Human Immunodeficiency Virus, this CTL response is progressively impaired due...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Clayton, Kiera L., Haaland, Matthew S., Douglas-Vail, Matthew B., Mujib, Shariq, Chew, Glen M., Ndhlovu, Lishomwa C., Ostrowski, Mario A.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4214929/
https://ncbi.nlm.nih.gov/pubmed/24337741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302663
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares