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Expansion of Dysfunctional Tim-3 Expressing Effector Memory CD8(+) T cells during SIV Infection in Rhesus Macaques
The T cell immunoglobulin- and mucin domain-containing molecule (Tim)-3 negative immune checkpoint receptor demarcates functionally exhausted CD8(+) T cells arising from chronic stimulation in viral infections like HIV. Tim-3 blockade leads to improved anti-viral CD8(+) T cell responses in vitro and...
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| Publicado no: | J Immunol |
|---|---|
| Main Authors: | , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4239185/ https://ncbi.nlm.nih.gov/pubmed/25348621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400961 |
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