TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection

HIV infection induces phenotypic and functional changes to CD8(+) T cells defined by the coordinated upregulation of a series of negative checkpoint receptors that eventually result in T cell exhaustion and failure to control viral replication. We report that effector CD8(+) T cells during HIV infec...

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Pubblicato in:PLoS Pathog
Autori principali: Chew, Glen M., Fujita, Tsuyoshi, Webb, Gabriela M., Burwitz, Benjamin J., Wu, Helen L., Reed, Jason S., Hammond, Katherine B., Clayton, Kiera L., Ishii, Naoto, Abdel-Mohsen, Mohamed, Liegler, Teri, Mitchell, Brooks I., Hecht, Frederick M., Ostrowski, Mario, Shikuma, Cecilia M., Hansen, Scott G., Maurer, Mark, Korman, Alan J., Deeks, Steven G., Sacha, Jonah B., Ndhlovu, Lishomwa C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704737/
https://ncbi.nlm.nih.gov/pubmed/26741490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005349
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